{"id":3239942,"date":"2024-07-19T08:33:43","date_gmt":"2024-07-19T12:33:43","guid":{"rendered":"https:\/\/www.futurity.org\/?p=3239942"},"modified":"2024-07-19T08:33:43","modified_gmt":"2024-07-19T12:33:43","slug":"diabetes-drug-reduces-lung-cancer-drug-resistance-3239942","status":"publish","type":"post","link":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/","title":{"rendered":"Diabetes drug may make lung cancer treatment more effective"},"content":{"rendered":"

A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer, according to a new study.<\/p>\n

Despite surgical and chemotherapy treatment, more than 50% of non-metastatic, non-small lung cancer patients see recurrences, in large part because of drug-resistant cancer cells.<\/p>\n

Researchers have identified a way to make these cells more susceptible to chemotherapy, says study author Jussuf Kaifi, a thoracic surgeon at the University of Missouri Health Care and an assistant professor of surgery at the university’s School of Medicine.<\/p>\n

“Traditional treatments for lung cancer, including chemotherapy, often have little to no effect on the cancer because of drug resistance<\/a>,” Kaifi says.<\/p>\n

“It is a major cause of mortality in patients, so finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes.”<\/p>\n

The study examined 10 non-small cell lung cancer tumors, half of which were identified as drug resistant. The drug-resistant tumors showed overexpression of a certain enzyme, AKR1B10. When treated with the diabetic neuropathy medication, epalrestat, the tumors became less drug resistant, causing their sensitivity to chemotherapy to significantly increase.<\/p>\n

Epalrestat is available in several countries and well-tolerated by patients, but it is not yet approved for use by the Food and Drug Administration in the United States. The medication is currently in high-level clinical trials as part of the FDA’s approval process. If given FDA approval, epalrestat could be fast-tracked as an anti-cancer drug for lung cancer patients.<\/p>\n

“In general, developing new drugs for cancer treatment is an extremely lengthy, expensive and inefficient process,” Kaifi says.<\/p>\n

“In contrast, ‘repurposing’ these drugs to other diseases is much faster and cheaper. In view of overcoming drug resistance<\/a>, epalrestat can rapidly be advanced to the clinic to improve cure rates in lung cancer patients.”<\/p>\n

The research appears in Clinical Cancer Research<\/em><\/a>.<\/p>\n

Source: University of Missouri<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients […]<\/p>\n","protected":false},"author":15392,"featured_media":3239972,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[135,1351,8880],"class_list":["post-3239942","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-medicine","tag-cancer","tag-lung-cancer","tag-medications","university-university-of-missouri"],"acf":[],"yoast_head":"\nDiabetes drug may make lung cancer treatment more effective - 糖心视频<\/title>\n<meta name=\"description\" content=\""...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes."\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diabetes drug may make lung cancer treatment more effective\" \/>\n<meta property=\"og:description\" content=\""...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes."\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\" \/>\n<meta property=\"og:site_name\" content=\"糖心视频\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-19T12:33:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"915\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Rochita Ghosh-U. Missouri\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:site\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rochita Ghosh-U. Missouri\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\"},\"author\":{\"name\":\"Rochita Ghosh-U. Missouri\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/3b3dd658f0eecb912fd859c793212b6a\"},\"headline\":\"Diabetes drug may make lung cancer treatment more effective\",\"datePublished\":\"2024-07-19T12:33:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\"},\"wordCount\":315,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg\",\"keywords\":[\"cancer\",\"lung cancer\",\"medications\"],\"articleSection\":[\"Health and Medicine\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\",\"url\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\",\"name\":\"Diabetes drug may make lung cancer treatment more effective - 糖心视频\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg\",\"datePublished\":\"2024-07-19T12:33:43+00:00\",\"description\":\"\\\"...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes.\\\"\",\"breadcrumb\":{\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg\",\"width\":1600,\"height\":915,\"caption\":\"(Credit: Getty Images)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.futurity.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Diabetes drug may make lung cancer treatment more effective\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.futurity.org\/#website\",\"url\":\"https:\/\/www.futurity.org\/\",\"name\":\"糖心视频\",\"description\":\"Research news from top universities.\",\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.futurity.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.futurity.org\/#organization\",\"name\":\"糖心视频\",\"url\":\"https:\/\/www.futurity.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"width\":332,\"height\":105,\"caption\":\"糖心视频\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\",\"https:\/\/x.com\/糖心视频News\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/3b3dd658f0eecb912fd859c793212b6a\",\"name\":\"Rochita Ghosh-U. Missouri\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/3a3e69d41e6a3f2c321a6e594eebafd4?s=96&d=mm&r=pg\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/3a3e69d41e6a3f2c321a6e594eebafd4?s=96&d=mm&r=pg\",\"caption\":\"Rochita Ghosh-U. Missouri\"},\"url\":\"https:\/\/www.futurity.org\/author\/u-missouri-ghosh\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Diabetes drug may make lung cancer treatment more effective - 糖心视频","description":"\"...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes.\"","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/","og_locale":"en_US","og_type":"article","og_title":"Diabetes drug may make lung cancer treatment more effective","og_description":"\"...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes.\"","og_url":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/","og_site_name":"糖心视频","article_publisher":"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","article_published_time":"2024-07-19T12:33:43+00:00","og_image":[{"width":1600,"height":915,"url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg","type":"image\/jpeg"}],"author":"Rochita Ghosh-U. Missouri","twitter_card":"summary_large_image","twitter_creator":"@糖心视频News","twitter_site":"@糖心视频News","twitter_misc":{"Written by":"Rochita Ghosh-U. Missouri","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#article","isPartOf":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/"},"author":{"name":"Rochita Ghosh-U. Missouri","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/3b3dd658f0eecb912fd859c793212b6a"},"headline":"Diabetes drug may make lung cancer treatment more effective","datePublished":"2024-07-19T12:33:43+00:00","mainEntityOfPage":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/"},"wordCount":315,"commentCount":0,"publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"image":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg","keywords":["cancer","lung cancer","medications"],"articleSection":["Health and Medicine"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/","url":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/","name":"Diabetes drug may make lung cancer treatment more effective - 糖心视频","isPartOf":{"@id":"https:\/\/www.futurity.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage"},"image":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg","datePublished":"2024-07-19T12:33:43+00:00","description":"\"...finding ways to circumvent drug and chemotherapy resistance is vital to improving patient outcomes.\"","breadcrumb":{"@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#primaryimage","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2024\/07\/diabetes-drug-lung-cancer-drug-resistance-1600.jpg","width":1600,"height":915,"caption":"(Credit: Getty Images)"},{"@type":"BreadcrumbList","@id":"https:\/\/www.futurity.org\/diabetes-drug-reduces-lung-cancer-drug-resistance-3239942\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.futurity.org\/"},{"@type":"ListItem","position":2,"name":"Diabetes drug may make lung cancer treatment more effective"}]},{"@type":"WebSite","@id":"https:\/\/www.futurity.org\/#website","url":"https:\/\/www.futurity.org\/","name":"糖心视频","description":"Research news from top universities.","publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.futurity.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.futurity.org\/#organization","name":"糖心视频","url":"https:\/\/www.futurity.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","width":332,"height":105,"caption":"糖心视频"},"image":{"@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","https:\/\/x.com\/糖心视频News"]},{"@type":"Person","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/3b3dd658f0eecb912fd859c793212b6a","name":"Rochita Ghosh-U. Missouri","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/3a3e69d41e6a3f2c321a6e594eebafd4?s=96&d=mm&r=pg","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/3a3e69d41e6a3f2c321a6e594eebafd4?s=96&d=mm&r=pg","caption":"Rochita Ghosh-U. Missouri"},"url":"https:\/\/www.futurity.org\/author\/u-missouri-ghosh\/"}]}},"_links":{"self":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/3239942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/users\/15392"}],"replies":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/comments?post=3239942"}],"version-history":[{"count":4,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/3239942\/revisions"}],"predecessor-version":[{"id":3239962,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/3239942\/revisions\/3239962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media\/3239972"}],"wp:attachment":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media?parent=3239942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/categories?post=3239942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/tags?post=3239942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}