{"id":2495742,"date":"2021-01-04T12:00:10","date_gmt":"2021-01-04T17:00:10","guid":{"rendered":"https:\/\/www.futurity.org\/?p=2495742"},"modified":"2021-01-04T12:01:10","modified_gmt":"2021-01-04T17:01:10","slug":"sunscreen-benzophenone-3-breast-cancer-2495742-2","status":"publish","type":"post","link":"https:\/\/www.futurity.org\/sunscreen-benzophenone-3-breast-cancer-2495742-2\/","title":{"rendered":"Stuff in sunscreen may play a part in breast cancer"},"content":{"rendered":"
The common sunscreen ingredient benzophenone-3, also known as oxybenzone or BP-3, can play a role in the development of mammary gland tumors, according to new research in mice.<\/p>\n
“Our set of results suggest caution in using BP-3 and the need to dig deeper to understand what it can do in mammary glands and tumorigenesis,” says Richard Schwartz, professor in the microbiology and molecular genetics department at Michigan State University, who has been researching the interaction of diet and cancer cell growth and proliferation for more than 12 years.<\/p>\n
“This is the first published result that makes a convincing case that BP-3 can change cancer outcomes.”<\/p>\n
The study appears in Oncotarget<\/em><\/a>.<\/p>\n Schwartz and coauthor Sandra Haslam, professor emeritus in the physiology department, previously<\/a> conducted successful experiments in mouse models that elucidated a relationship between diets high in saturated animal fats with higher incidence and shorter latency of breast cancer.<\/p>\n “We were excited about the results of our diet experiments, but the [the National Institute for Environmental Health 糖心视频s (NIEHS)] was interested in funding a chemical study, so we decided to combine the two,” Schwartz says.<\/p>\n The researchers landed on BP-3, a ubiquitous and easily absorbed chemical. A recent report<\/a> in the Journal of the American Medical Association<\/em> found that after just one heavy application of sunscreen<\/a>, blood levels of BP-3 exceeded the Federal Drug Administration’s guidance for chemicals at a threshold of toxicological concern, and the Centers for Disease Control found BP-3 in 98% of adult urine samples.<\/p>\n BP-3 is also a suspected endocrine disrupting chemical (EDC), substances that interfere with hormonally regulated processes the body uses for a wide range of functions, including mammary gland development.<\/p>\n Using a mouse model where the mammary glands lacked a gene often mutated in human breast cancer as a proxy for women growing from puberty into adulthood, the researchers put the mice under three distinct dietary regimes: a lifelong low-fat diet, a high-fat diet during puberty switching to a low-fat diet during reproductive years, and vice versa.<\/p>\n