{"id":2123172,"date":"2019-08-02T14:52:53","date_gmt":"2019-08-02T18:52:53","guid":{"rendered":"https:\/\/www.futurity.org\/?p=2123172"},"modified":"2019-08-02T14:55:36","modified_gmt":"2019-08-02T18:55:36","slug":"obafluorin-drug-resistance-enzymes-2123172-2","status":"publish","type":"post","link":"https:\/\/www.futurity.org\/obafluorin-drug-resistance-enzymes-2123172-2\/","title":{"rendered":"Next antibiotic may come from dirt bacteria"},"content":{"rendered":"

New insight about a broad spectrum antibiotic agent, obafluorin, made from a fluorescent strain of soil bacteria might offer a powerful antidote to antibiotic resistance, researchers say.<\/p>\n

Understanding how antibiotic scaffolds construct in nature can help prospect for new classes of antibiotics through DNA sequencing and genome mining. Scientists used this knowledge to help solve the X-ray crystal structure of the enzyme that makes obafluorin.<\/p>\n

A multi-part enzyme called a nonribosomal peptide synthetase produces the highly reactive beta-lactone ring that is responsible for obafluorin’s antimicrobial activity, researchers say.<\/p>\n