{"id":1879222,"date":"2018-10-02T12:25:30","date_gmt":"2018-10-02T16:25:30","guid":{"rendered":"https:\/\/www.futurity.org\/?p=1879222"},"modified":"2018-10-03T14:39:05","modified_gmt":"2018-10-03T18:39:05","slug":"sleep-disorders-circadian-rhythm-1879222","status":"publish","type":"post","link":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/","title":{"rendered":"How a body clock blood test could catch more sleep disorders"},"content":{"rendered":"<p>Recently, researchers developed a new blood test that can reveal if an individual&#8217;s circadian rhythm is running too fast or too slow. The test has the potential to advance treatments of a variety of disorders and diseases.<\/p>\n<p>In this podcast, Phyllis Zee explains the test and how circadian clocks have an impact far beyond sleep.<\/p>\n<p><iframe loading=\"lazy\" style=\"border: none;\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/7055533\/height\/90\/theme\/custom\/autoplay\/no\/autonext\/no\/thumbnail\/yes\/preload\/no\/no_addthis\/no\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>Zee is the chief of sleep medicine in the neurology department at Northwestern University&#8217;s Feinberg School of Medicine, a professor of neurology, and director for the Center for Circadian and Sleep Medicine.<\/p>\n<p>About 70 million Americans suffer from sleep problems such as sleep apnea, insomnia, and restless leg syndrome. But physicians often miss circadian rhythm sleep-wake disorders, Zee says.<\/p>\n<p>&#8220;They present like somebody who may have insomnia or somebody who may have what we call hypersomnia, excessive daytime sleepiness, but it&#8217;s actually due to an alteration or pathology in the circadian clock system,&#8221; she says.<\/p>\n<p>Everyone has an internal clock that produces circadian rhythms, intrinsic rhythms that keep a time of approximately 24 hours. Light-dark cycles don&#8217;t drive them; instead, these rhythms are generated at a molecular level. This circadian clock system exists in every single cell of the human body and is regulated by a core clock genetic mechanism. There are also more than 10 &#8220;clock genes&#8221; that reside in the nucleus of cells and produce proteins that determine whether you are a &#8220;night owl&#8221; or &#8220;morning lark.&#8221;<\/p>\n<p>&#8220;How quickly these proteins get degradated in the cytoplasm determines whether you&#8217;re going to be an owl or a lark. So if you&#8217;re an owl, it is because your clock genetic system is taking a little slower than the 24-hour cycle,&#8221; Zee says. &#8220;If you&#8217;re a lark (your clock) is probably going a little faster. That&#8217;s why larks wake up early, because they finished that circadian cycle, that molecular circadian cycle, a little faster than the rotation of the earth on its axis around the sun.&#8221;<\/p>\n<p>Zee was part of the research team that developed the blood test to identify individuals&#8217; precise internal clock times as compared to external time. The test, called Time Signature, requires only two blood draws. Previously, measurements this precise required a costly and laborious process of taking samples every hour over a span of multiple hours.<\/p>\n<p>&#8220;This is a first step towards providing what I call a biomarker, a time based biomarker, for circadian timing, and it isn&#8217;t just for sleep,&#8221; Zee says.<\/p>\n<p>The blood test could advance personalized medicine and help physicians determine the best time of the day for a person to take certain medications, such as blood pressure medication, and other medications that target &#8220;clock genes.&#8221;<\/p>\n<p>&#8220;We can maximize not just the effectiveness, but also decrease the side effects of medications,&#8221; Zee says.<\/p>\n<p>The recent paper about Time Signature test is a proof of concept, to show that it works, Zee says. The researchers performed the study with healthy young people; next it will move into patient populations.<\/p>\n<p>The study outlining the test appears in the <a href=\"https:\/\/doi.org\/10.1073\/pnas.1800314115\" target=\"_blank\" rel=\"noopener\"><em>Proceedings of the National Academy of 糖心视频s<\/em><\/a>.<\/p>\n<p><em>Source: <a href=\"https:\/\/www.feinberg.northwestern.edu\/research\/news\/podcast\/sleep-and-circadian-rhythm-disorders.html\">Northwestern University<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recently, researchers developed a new blood test that can reveal if an individual&#8217;s circadian rhythm [&hellip;]<\/p>\n","protected":false},"author":5502,"featured_media":1879322,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"chat","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[1829,8897,1181],"class_list":["post-1879222","post","type-post","status-publish","format-chat","has-post-thumbnail","hentry","category-health-medicine","tag-blood-tests","tag-circadian-rhythms","tag-sleep","post_format-post-format-chat","university-northwestern-university"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.8 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How a body clock blood test could catch more sleep disorders - 糖心视频<\/title>\n<meta name=\"description\" content=\"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How a body clock blood test could catch more sleep disorders\" \/>\n<meta property=\"og:description\" content=\"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\" \/>\n<meta property=\"og:site_name\" content=\"糖心视频\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\" \/>\n<meta property=\"article:published_time\" content=\"2018-10-02T16:25:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-03T18:39:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"915\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Erin Spain-Northwestern\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:site\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Erin Spain-Northwestern\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\"},\"author\":{\"name\":\"Erin Spain-Northwestern\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/c5d14dffa985ddab625dbdc203d87703\"},\"headline\":\"How a body clock blood test could catch more sleep disorders\",\"datePublished\":\"2018-10-02T16:25:30+00:00\",\"dateModified\":\"2018-10-03T18:39:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\"},\"wordCount\":525,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg\",\"keywords\":[\"blood tests\",\"circadian rhythms\",\"sleep\"],\"articleSection\":[\"Health and Medicine\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\",\"url\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\",\"name\":\"How a body clock blood test could catch more sleep disorders - 糖心视频\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg\",\"datePublished\":\"2018-10-02T16:25:30+00:00\",\"dateModified\":\"2018-10-03T18:39:05+00:00\",\"description\":\"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg\",\"width\":1600,\"height\":915,\"caption\":\"(Credit: Getty Images)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.futurity.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"How a body clock blood test could catch more sleep disorders\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.futurity.org\/#website\",\"url\":\"https:\/\/www.futurity.org\/\",\"name\":\"糖心视频\",\"description\":\"Research news from top universities.\",\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.futurity.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.futurity.org\/#organization\",\"name\":\"糖心视频\",\"url\":\"https:\/\/www.futurity.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"width\":332,\"height\":105,\"caption\":\"糖心视频\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\",\"https:\/\/x.com\/糖心视频News\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/c5d14dffa985ddab625dbdc203d87703\",\"name\":\"Erin Spain-Northwestern\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/d1a5a20cef5b24ab3115fcb0a67addff?s=96&d=mm&r=pg\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/d1a5a20cef5b24ab3115fcb0a67addff?s=96&d=mm&r=pg\",\"caption\":\"Erin Spain-Northwestern\"},\"url\":\"https:\/\/www.futurity.org\/author\/northwestern-spain\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"How a body clock blood test could catch more sleep disorders - 糖心视频","description":"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/","og_locale":"en_US","og_type":"article","og_title":"How a body clock blood test could catch more sleep disorders","og_description":"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.","og_url":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/","og_site_name":"糖心视频","article_publisher":"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","article_published_time":"2018-10-02T16:25:30+00:00","article_modified_time":"2018-10-03T18:39:05+00:00","og_image":[{"width":1600,"height":915,"url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg","type":"image\/jpeg"}],"author":"Erin Spain-Northwestern","twitter_card":"summary_large_image","twitter_creator":"@糖心视频News","twitter_site":"@糖心视频News","twitter_misc":{"Written by":"Erin Spain-Northwestern","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#article","isPartOf":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/"},"author":{"name":"Erin Spain-Northwestern","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/c5d14dffa985ddab625dbdc203d87703"},"headline":"How a body clock blood test could catch more sleep disorders","datePublished":"2018-10-02T16:25:30+00:00","dateModified":"2018-10-03T18:39:05+00:00","mainEntityOfPage":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/"},"wordCount":525,"commentCount":0,"publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"image":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg","keywords":["blood tests","circadian rhythms","sleep"],"articleSection":["Health and Medicine"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/","url":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/","name":"How a body clock blood test could catch more sleep disorders - 糖心视频","isPartOf":{"@id":"https:\/\/www.futurity.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage"},"image":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg","datePublished":"2018-10-02T16:25:30+00:00","dateModified":"2018-10-03T18:39:05+00:00","description":"In this podcast, a sleep expert who helped develop the blood test that can tell if your body clock is off explains how it works and what it could mean.","breadcrumb":{"@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#primaryimage","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2018\/10\/man-sleeping-at-desk_1600.jpg","width":1600,"height":915,"caption":"(Credit: Getty Images)"},{"@type":"BreadcrumbList","@id":"https:\/\/www.futurity.org\/sleep-disorders-circadian-rhythm-1879222\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.futurity.org\/"},{"@type":"ListItem","position":2,"name":"How a body clock blood test could catch more sleep disorders"}]},{"@type":"WebSite","@id":"https:\/\/www.futurity.org\/#website","url":"https:\/\/www.futurity.org\/","name":"糖心视频","description":"Research news from top universities.","publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.futurity.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.futurity.org\/#organization","name":"糖心视频","url":"https:\/\/www.futurity.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","width":332,"height":105,"caption":"糖心视频"},"image":{"@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","https:\/\/x.com\/糖心视频News"]},{"@type":"Person","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/c5d14dffa985ddab625dbdc203d87703","name":"Erin Spain-Northwestern","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/d1a5a20cef5b24ab3115fcb0a67addff?s=96&d=mm&r=pg","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d1a5a20cef5b24ab3115fcb0a67addff?s=96&d=mm&r=pg","caption":"Erin Spain-Northwestern"},"url":"https:\/\/www.futurity.org\/author\/northwestern-spain\/"}]}},"_links":{"self":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1879222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/users\/5502"}],"replies":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/comments?post=1879222"}],"version-history":[{"count":5,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1879222\/revisions"}],"predecessor-version":[{"id":1879632,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1879222\/revisions\/1879632"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media\/1879322"}],"wp:attachment":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media?parent=1879222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/categories?post=1879222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/tags?post=1879222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}