{"id":1561742,"date":"2017-10-03T07:50:44","date_gmt":"2017-10-03T11:50:44","guid":{"rendered":"http:\/\/www.futurity.org\/?p=1561742"},"modified":"2017-10-03T07:50:44","modified_gmt":"2017-10-03T11:50:44","slug":"mitochondria-mtor-cells-1561742","status":"publish","type":"post","link":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/","title":{"rendered":"Mitochondria keep nutrient-starved cells alive"},"content":{"rendered":"

Researchers have discovered a mechanism through which mitochondria, the energy factory of our body\u2019s cells, play a role in preventing cells from dying when the cells are deprived of nutrients.<\/p>\n

The finding points to a potential target for next-generation cancer drugs.<\/p>\n

Cells in our body grow in size, mass, and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin).<\/p>\n

Nahum Sonenberg, professor of biochemistry at McGill University and a senior author of the new research, discovered years ago that mTOR also controls protein expression in all human cells. In particular, mTOR targets the selective synthesis of proteins destined for the mitochondria, the bacteria-like structures in all our cells that generate the energy needed for cells to grow and divide.<\/p>\n

In the new research, Sonenberg and his team show that mTOR also controls the expression of proteins that alter the structure and function of mitochondria\u2014thereby protecting cells from dying.<\/p>\n

How cells come back from the brink of death<\/a><\/h5>\n

Their work has implications for cancer therapy, since new drugs that act on mTOR are currently in clinical trials for cancer. While the treatments are effective in arresting the expansion and growth of cancer cells, the cells continue to survive, despite a shortage of nutrients. The new study reveals that mitochondria help keep these cells alive by fusing together and blocking a central point in a cell death pathway, called apoptosis.<\/p>\n

This advance offers clues to develop combination therapies that could promote cancer-cell death by reversing the protection offered by mitochondria, the researchers say.<\/p>\n

The research appears in Molecular Cell<\/em><\/a>.<\/p>\n

Source: McGill University<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers have discovered a mechanism through which mitochondria, the energy factory of our body\u2019s cells, […]<\/p>\n","protected":false},"author":90,"featured_media":1561782,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[22,2157],"class_list":["post-1561742","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-technology","tag-cells","tag-mitochondria","university-mcgill-university"],"acf":[],"yoast_head":"\nMitochondria keep nutrient-starved cells alive - 糖心视频<\/title>\n<meta name=\"description\" content=\"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitochondria keep nutrient-starved cells alive\" \/>\n<meta property=\"og:description\" content=\"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\" \/>\n<meta property=\"og:site_name\" content=\"糖心视频\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\" \/>\n<meta property=\"article:published_time\" content=\"2017-10-03T11:50:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"915\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cynthia Lee-McGill\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:site\" content=\"@糖心视频News\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Cynthia Lee-McGill\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\"},\"author\":{\"name\":\"Cynthia Lee-McGill\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/3f53dfe0fb2d63ee18319d538a4f1055\"},\"headline\":\"Mitochondria keep nutrient-starved cells alive\",\"datePublished\":\"2017-10-03T11:50:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\"},\"wordCount\":274,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg\",\"keywords\":[\"cells\",\"mitochondria\"],\"articleSection\":[\"糖心视频 and Technology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\",\"url\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\",\"name\":\"Mitochondria keep nutrient-starved cells alive - 糖心视频\",\"isPartOf\":{\"@id\":\"https:\/\/www.futurity.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg\",\"datePublished\":\"2017-10-03T11:50:44+00:00\",\"description\":\"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg\",\"width\":1600,\"height\":915,\"caption\":\"(Credit: Getty Images)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.futurity.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mitochondria keep nutrient-starved cells alive\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.futurity.org\/#website\",\"url\":\"https:\/\/www.futurity.org\/\",\"name\":\"糖心视频\",\"description\":\"Research news from top universities.\",\"publisher\":{\"@id\":\"https:\/\/www.futurity.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.futurity.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.futurity.org\/#organization\",\"name\":\"糖心视频\",\"url\":\"https:\/\/www.futurity.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"contentUrl\":\"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png\",\"width\":332,\"height\":105,\"caption\":\"糖心视频\"},\"image\":{\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226\",\"https:\/\/x.com\/糖心视频News\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/3f53dfe0fb2d63ee18319d538a4f1055\",\"name\":\"Cynthia Lee-McGill\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.futurity.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/7f0170a16893405d829da81dfc38c593?s=96&d=mm&r=pg\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/7f0170a16893405d829da81dfc38c593?s=96&d=mm&r=pg\",\"caption\":\"Cynthia Lee-McGill\"},\"url\":\"https:\/\/www.futurity.org\/author\/mcgill-lee\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Mitochondria keep nutrient-starved cells alive - 糖心视频","description":"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/","og_locale":"en_US","og_type":"article","og_title":"Mitochondria keep nutrient-starved cells alive","og_description":"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.","og_url":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/","og_site_name":"糖心视频","article_publisher":"https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","article_published_time":"2017-10-03T11:50:44+00:00","og_image":[{"width":1600,"height":915,"url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg","type":"image\/jpeg"}],"author":"Cynthia Lee-McGill","twitter_card":"summary_large_image","twitter_creator":"@糖心视频News","twitter_site":"@糖心视频News","twitter_misc":{"Written by":"Cynthia Lee-McGill","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#article","isPartOf":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/"},"author":{"name":"Cynthia Lee-McGill","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/3f53dfe0fb2d63ee18319d538a4f1055"},"headline":"Mitochondria keep nutrient-starved cells alive","datePublished":"2017-10-03T11:50:44+00:00","mainEntityOfPage":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/"},"wordCount":274,"commentCount":0,"publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"image":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg","keywords":["cells","mitochondria"],"articleSection":["糖心视频 and Technology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/","url":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/","name":"Mitochondria keep nutrient-starved cells alive - 糖心视频","isPartOf":{"@id":"https:\/\/www.futurity.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage"},"image":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage"},"thumbnailUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg","datePublished":"2017-10-03T11:50:44+00:00","description":"Mitochondria's role in saving dying cells may open up new paths for cancer treatment.","breadcrumb":{"@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#primaryimage","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2017\/10\/wilted-flower-on-pink_1600.jpg","width":1600,"height":915,"caption":"(Credit: Getty Images)"},{"@type":"BreadcrumbList","@id":"https:\/\/www.futurity.org\/mitochondria-mtor-cells-1561742\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.futurity.org\/"},{"@type":"ListItem","position":2,"name":"Mitochondria keep nutrient-starved cells alive"}]},{"@type":"WebSite","@id":"https:\/\/www.futurity.org\/#website","url":"https:\/\/www.futurity.org\/","name":"糖心视频","description":"Research news from top universities.","publisher":{"@id":"https:\/\/www.futurity.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.futurity.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.futurity.org\/#organization","name":"糖心视频","url":"https:\/\/www.futurity.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","contentUrl":"https:\/\/www.futurity.org\/wp\/wp-content\/uploads\/2019\/05\/logo-2018.png","width":332,"height":105,"caption":"糖心视频"},"image":{"@id":"https:\/\/www.futurity.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pages\/糖心视频\/143906865226","https:\/\/x.com\/糖心视频News"]},{"@type":"Person","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/3f53dfe0fb2d63ee18319d538a4f1055","name":"Cynthia Lee-McGill","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.futurity.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7f0170a16893405d829da81dfc38c593?s=96&d=mm&r=pg","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7f0170a16893405d829da81dfc38c593?s=96&d=mm&r=pg","caption":"Cynthia Lee-McGill"},"url":"https:\/\/www.futurity.org\/author\/mcgill-lee\/"}]}},"_links":{"self":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1561742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/users\/90"}],"replies":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/comments?post=1561742"}],"version-history":[{"count":6,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1561742\/revisions"}],"predecessor-version":[{"id":1561832,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/posts\/1561742\/revisions\/1561832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media\/1561782"}],"wp:attachment":[{"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/media?parent=1561742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/categories?post=1561742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.futurity.org\/wp-json\/wp\/v2\/tags?post=1561742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}